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Our laboratory studies the molecular pharmacology of the G-protein coupled receptors. We are located at the University of Washington School of Medicine in D-430/431 of the Health Sciences Building.
The goal of our research is to understand the molecular mechanisms of drug action at G-protein coupled receptors. We are currently focused on deciphering how GPCRs are organized as macromolecular protein complexes in cell membranes. We recently revealed the alpha1D-adrenergic receptor, a key regulator of cardiovascular, nervous system, and urinary function, associates with the dystrophin-associated protein complex through a PDZ-domain interaction. Proteomic studies identified a novel member of the complex, alpha-catulin. Our current goals are to:
1) Determine the functional importance of alpha-catulin for alpha1D-AR/DAPC signalosome signaling in human cells.
2) Determine how many human GPCRs associate with the alpha-catulin/DAPC.
Understanding how GPCRs are organized as macromolecular complexes in human cells may identify novel drug target interfaces for treating disease.