- Recommended method
  - Use with caution
  - Do not use

Labor & Delivery Regional Medications

 

Drug / Dosages Labor:
Intermittent bolus
(Epidural)
Labor:
Infusion
(Epidural)
Delivery
(Epidural)
C/Section
(Epidural)
C/Section
(Spinal)
bupivacaine TD + 5ml 0.25%
onset: 10-20’
duration: 90-120’
TD, then
• 0.125% plain, or
• 0.0625% with
  2 mcg/ml fentanyl
start @ 8-12ml/hr
TD + 5+5ml 0.25%
onset: 10-15’
duration: 90-120’
----------------------
( 0.5% forceps/motor block)
TD + 5+5ml 0.5%
+ 50mcg fentanyl,
5ml + 5 + ... [to T4]
onset: 10-15’
duration: 90-120’
~12mg 0.75% hyperbaric (with dextrose)
+/- 100mcg epi
+/- 250mcg MS-PF
lidocaine TD+ 5ml 1%
onset: 5-10’
duration: ~60’
  TD + 5+5ml 1%
onset: 5-10’
duration: ~60’
----------------------
(or 2% for forceps)
TD + 5+5ml 2%
50mcg fentanyl,
5ml + 5 + ... [to T4]
onset: ~5’
duration: 60’
~70mg 5% hyperbaric (with dextrose)
+/- 100mcg epi
chloroprocaine
(Nesacaine)
    TD + 5+5ml 2%
onset: 5’
duration: 45-60’
----------------------
(or 3% for forceps)
TD + 5+5ml 3%
5ml + 5 + ... [to T4]
onset: 5’
duration: 45-60’
 
ropivicaine
(Naropin)
TD + 5ml 0.2%
onset: 10-15’
duration: ~90’
TD, then
0.1% with
   2 mcg/ml fentanyl
start @ 8-12ml/hr
TD+ 5+5ml 0.2%
onset: 10-15'
duration: ~90-120'
   
meperidine
(Demerol)
TD + 25mg in
   5ml NS (PF)
onset 5-15’
duration: 2-4hrs
(up to 3 doses)
       

TD* - Test dose of 3ml 0.25% bupivacaine with 1:200,000 epinephrine or 3 ml 2% lidocaine with 1:200,000 epinephrine to rule out intravascular/intrathecal injection.

 

Rational drug selection guide

Drug Advantages Disadvantages
bupivacaine
  • less relative motor block
  • long duration
  • fetal safety
  • greater maternal protein binding than lidocaine
  • relatively greater cardiotoxicity
  • long duration
  • slow onset
  • lidocaine
    • rapid onset
    • short duration
  • more motor block
  • short duration
  • greater fetal exposure than bipivacaine (?)
  • chloroprocaine
    (Nesacaine)
    • fetal safety (due to rapid breakdown)
    • very rapid onset
    • short duration
    • low systemic toxicity
  • neurotoxicity (preservatives?)
  • short shelf life if PF
  • short duration
  • antagonizes spinal opiods, other local anesthetics
  • allergenic (PABA)
  • most tachyphylaxis
  • ropivicaine
    (Naropin)
    • less cardiotoxicity than bupivicaine
    • long duration
    • possible less motor block
  • potency not clearly established
  • shorter clinical experience with agent
  • higher cost
  • meperidine
    (Demerol)
    • allows maternal ambulation
    • no motor block
    • some local anesthetic effects
    • long duration
  • potential fetal resp. depression, espcially by metabolites
  • long half-life of nor-meperidine
  • paucity of scientific data for use in labor
  • inadequate relief for most late active labor