Welcome to the Asbury Lab website.

Our laboratory studies the mitotic spindle, a molecular machine that organizes and separates duplicated chromosomes during cell division, thereby ensuring equal partitioning of the genetic material. To uncover how this machine operates, we are reconstituting spindle functions using pure components and applying new biophysical tools for manipulating and tracking individual molecules, such as laser trapping and ultrasensitive fluorescence microscopy.

metaphase

Mitosis: A human retinal epithelial cell seen in metaphase and (on mouse-over) anaphase. The chromosomes (green) and spindle microtubules (red) were highlighted by fixing the cells and staining with DAPI and anti-alpha tubulin. Photos courtesy of Jason Stumpff.