Changes in Beagle 4.0 ========================= * Added use of a standard file format (VCF) for input/output. * Added a more powerful IBD segment detection algorithm: Refined IBD. * Added support for multi-threaded computation. * Added support for multi-allelic variants. * Added a faster imputation algorithm. * Eliminated use of temporary files. * Added a sliding window to control memory use. Beagle 4.0, r1274 release notes =============================== * Increased default window parameter from 24000 to 50000. * Increased default buildwindow parameter from 500 to 1200. * Improved computational efficiency of model-building algorithm. * Included reference haplotypes in model when performing IBD detection. Beagle 4.0, r1389 release notes =============================== * Decreased default singlescale parameter from 1.0 to 0.8. * Improved computational efficiency of model-building algorithm. * Improved source code architecture. Beagle 4.0, r1399 release notes (Mar 3, 2015) ============================================= * maintenance release: fixed error in sample identifiers printed to .warnings output file. Beagle 4.1 (03Oct15.284) release notes ============================================= * Added a new, fast imputation algorithm. * Added a new, more accurate phasing algorithm. * Added support for bref-compressed reference files. * Eliminated the following command-line parameters: 1) usephase 2) nsamples 3) burnin-its 4) phase-its 5) imputation-its 6) singlescale 7) duoscale 8) trioscale * Added the following command-line parameters: 1) niterations 2) modelscale (replaces singlescale parameter) 3) ne 4) err 5) cluster * Removed option for modeling parent-offspring duos and trios during phasing (the ped parameter has no effect). These options are still available in Beagle 4.0. * Require gt command line argument when performing imputation of ungenotyped markers or identity-by-descent segment detection. * Change output genotypes to be unphased when gl or gtgl command line argument is used. Beagle 4.1 (09Nov15.d2a) release notes ============================================= * Major update to the bref program to add support for structural variants. Note: Older versions of bref are not compatible with the current version. * Minor update to fix bugs. Beagle 4.1 (14Jan16.841) release notes ============================================= * Expand effect of nthreads parameter to common ForkJoinPool. * Changed default nthreads parameter from 1 to 4. Beagle 4.1 (27Jan16.aae) release notes ============================================= * Minor update to fix a bug in handling structural variants. * Remove DS field from VCF output when there are there are no imputed markers. Beagle 4.1 (09Feb16.2b7) release notes ============================================= * Improve an error message. * Change default number of threads to be number of processors on host. Beagle 4.1 (22Feb16.8ef) release notes ============================================= * Minor update to the model-building algorithm. * Minor update to fix bugs. Beagle 4.1 (15Apr16.63e) release notes Beagle 4.1 (22Apr16.1cf) release notes ============================================= * Minor updates to fix a bug in the genotype calling algorithm. Beagle 4.1 (03May16.862) release notes ============================================= * Improve INFO field accuracy for low-MAF markers. * Add "IMP" INFO field to mark imputed markers. Beagle 4.1 (14Jun16.dd3) release notes ============================================= * Improve accuracy and computational efficiency of genotype imputation. Beagle 4.1 (16Jun.7e4) release notes ============================================= * Simplify code for writing BGZIP files. Beagle 4.1 (27Jun16.b16) release notes ============================================= * Correct an output VCF file meta-information line. Beagle 4.1 (05Jul16.587) release notes ============================================= * Minor update to fix a bug. Beagle 4.1 (23Jul16.fb0) release notes ============================================= * Minor update to fix a bug. Beagle 4.1 (27Jul16.86a) release notes ============================================= * Improve computational efficiency of genotype imputation. Beagle 4.1 (21Jan17.6cc) release notes ============================================= * add gzip compression to IBD and HBD output files. * add ibdcm parameter to apply length threshold to output IBD/HBD segments. Beagle 4.1 (08Jun17.d8b) release notes ============================================= * Fix bug in reading bref files when impute=false