Lutz Lab

Department of Bioengineering, University of Washington

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Journal publications

· Lutz, Liang, Fu, Ramachandran, Kauffman, & Yager. “Dissolvable fluidic time delays for programming multi-step assays in instrument-free paper diagnostics,” Lab on a Chip (2013), DOI: 10.1039/c3lc50178g. [LINK]

o See commentary in ”Microfluidic sugar paper,” Chemistry World, May 30, 2013. [LINK]

o See the Viewpoint article by George Whitesides highlighting our paper, Lab on a Chip (2013), DOI: 10.1039/c3lc90066e. [LINK]

· Dharmaraja, Lafleur, Byrnes, Kauffman, Buser, Toley, Fu, Yager, & Lutz. "Programming paper networks for point of care diagnostics," Proceedings of SPIE, 8615, Microfluidics, BioMEMS, and Medical Microsystems XI, 86150X (2013); DOI: 10.1117/12.2006138. [LINK]

· Ramachandran, Singhal, Mckenzie, Osborn, Arjyal, Dongol, Baker, Basnyat, Farrar, Dolecek, Domingo, Yager, & Lutz. “A Rapid, Multiplexed, High-Throughput Flow-Through Membrane Immunoassay: A Convenient Alternative to ELISA,” Diagnostics, Special Issue: Feature Papers (2013), 3(2), 244-260, DOI: 10.3390/diagnostics3020244. [LINK]

· Lutz, Venkataraman, & Browd. “New and Improved Ways to Treat Hydrocephalus: pursuit of a smart shunt,” Invited review in Surgical Neurology International (2013), 4, Suppl S1:38-50, DOI: 10.4103/2152-7806.109197. [LINK]

· Lafleur, Stevens, McKenzie, Ramachandran, Spicar-Mihalic, Singhal, Arjyal, Osborn, Kauffman, Yager, Lutz. “Progress toward multiplexed sample-to-result detection in low resource settings using microfluidic immunoassay cards,” Lab on a Chip, DOI: 10.1039/c2lc20751f (2012). [LINK]

· Lutz, Trinh, Ball, Fu, Yager. “Two-dimensional paper networks: programmable fluidic disconnects for multi-step processes in shaped paper,” Lab on a Chip, DOI: c1LC20758j (2011). [LINK]

· Osborn, J., Lutz, B., Fu, E., Kauffman, P., Stevens, D., Yager, P. “Microfluidics without pumps: reinventing the T-sensor and H-filter in paper networks,” Lab on a Chip, DOI: c004821f (2010). [LINK] [COVER IMAGE]

· Fu, E., Lutz, B., Kauffman, P., and Yager, P. “Controlled reagent transport in disposable 2D paper networks,” Lab on a Chip, DOI: 10.1039/b919614e (2010). [LINK]

· Fu, E., Kauffman, P., Lutz, B., and Yager, P. “Chemical signal amplification in two-dimensional paper networks,” Sensors & Actuators B, 149, 325–328 (2010). [LINK]

· Kauffman, P., Fu, E., Lutz, B., and Yager, P. “Visualization and measurement of flow in two-dimensional paper networks,” Lab on a Chip, DOI: 10.1039/c004766j (2010). [LINK]

· McKenzie, K.G., Lafleur, L.K., Lutz, B.R. and Yager, P., “Rapid protein depletion from complex samples using a bead-based microfluidic device for the point of care,” Lab on a Chip, DOI: 10.1039/b913806d (2009). [LINK]

· Lutz, B., Dentinger, C. Sun, L., Nguyen, L., Zhang, J., Chmura, AJ, Allen, A., Chan, S., Knudsen, B. “Spectral analysis of multiplex Raman probe signatures,” ACS Nano, 2, 2306–2314 (2008). [LINK]

· Lutz, B., Dentinger, C. Sun, L., Nguyen, L., Zhang, J., Chmura, AJ, Allen, A., Chan, S., Knudsen, B. “Raman Nanoparticle Probes for Antibody-based Protein Detection in Tissues,” Journal of Histochemistry and Cytochemistry, 56 (4), 371-379, (2008). [LINK]

· Sun, L.; Sung, K.-B.; Dentinger, C.; Lutz, B.R.; Nguyen, L.; Zhang, J.; Qin, H.; Yamakawa, M.; Cao, M.; Lu, Y.; Chmura, A.J.; Zhu, J.; Su, X.; Berlin, A.; Chan, C.; Knudsen, B. “Composite organic-inorganic nanoparticles as Raman labels for tissue analysis,” Nano Letters, 7, 351-356 (2007). [LINK]

· Lutz, B.R.; Chen, J.; & Schwartz, D.T. “Hydrodynamic tweezers: non-contact trapping of single cells using steady streaming microeddies,” Analytical Chemistry, 78, 5429-5435 (2006). [LINK]

· Lutz, B.R.; Chen, J.; & Schwartz, D.T. “Characterizing homogeneous chemistry using well-mixed microeddies,” Analytical Chemistry, 78, 1606-1620 (2006). [LINK]

· Lutz, B.R.; Chen, J.; & Schwartz, D.T. “Microscopic steady streaming eddies created around short cylinders in a channel: flow visualization and Stokes layer scaling,” Physics of Fluids, 17, 023601 (2005). [LINK]

· Lutz, B.R.; Chen, J.; & Schwartz, D.T. “Microfluidics without microfabrication,” Proceedings of the National Academy of Sciences of the United States of America, 100, 4395-4398 (2003). [LINK]

· Nolan, P.D.; Lutz, B.R.; Tanaka, P.L.; Davis, J.E.; & Mullins, C.B. “Molecularly chemisorbed intermediates to oxygen adsorption on Pt(111): A molecular beam and electron energy-loss spectroscopy study. Journal of Chemical Physics, 111, 3696-3704 (1999).

· Nolan P.D.; Lutz B.R.; Tanaka P.L.; Meyer R.J.; Brown S.J.; & Mullins C.B. “Evidence of a molecular chemisorption-mediated mechanism for high translational energy oxygen adsorption on Pt(100)-hex-R0.7 degrees.” Chemical Physics Letters, 309, 111-116 (1999).

· Nolan, P.D.; Lutz, B.R.; Tanaka, P.L.; & Mullins, C.B. “Direct verification of a high-translational-energy molecular precursor to oxygen dissociation on Pd(111).” Surface Science, 419, L107-L113 (1998).

· Nolan, P.D.; Lutz, B.R.; Tanaka, P.L.; Davis, J.E.; & Mullins, C.B. “Translational energy selection of molecular precursors to oxygen adsorption on Pt(111).” Physical Review Letters, 81, 3179-3182 (1998).

· Lutz, B.R.; Stanglmaier, R.H.; Matthews, R.D.; Cohen, J.T.; & Wicker, R. "The effects of fuel composition, system design, and operating conditions on in-system vaporization and hot start of a liquid-phase LPG injection system," Society of Automotive Engineers International Spring Fuels & Lubricants Meeting, Paper 981388; also in Combustion Processes in Engines Utilizing Gaseous Fuels, SAE Special Publication SP-1371 (1998).

· Lutz, B.R.; Reinhart, M.; Ku, J.; Huang, Y.; Belle, S.; Hollowell, B.; Sternberg, J.; Wu, D-Y.; Matthews, R.D.; & Hall, M.J. "Conversion of a 1997 Malibu to dedicated E85 with emphasis on cold start and cold drivability," Society of Automotive Engineers Special Publication SP-1453 (1998).

Patent applications

· Lutz, B. and Browd, S. Drainage Systems for Body Fluids and Associated Methods, PCT Patent Application (2011).

· Paul Yager, Lisa Lafleur, Barry Lutz, Paolo Spicar-Mihalic, Dean Stevens. Microfluidic Systems Incorporating Flow-Through Membranes, U.S. National Phase Patent Application 13/060,664 (2011).

· Capillarity-based devices for performing chemical processes and associated systems and methods, PCT Application PCT/US2010/061675 (2010).

· Lafleur, L., Lutz, B., Spicar-Mihalic, P., Stevens, D., Yager, P. Method for incorporating flow-through membranes in microfluidic systems. U.S. Patent Application (2009).

· Lutz, B.R. and Schwartz, D.T. Steady streaming particle traps, U.S. Patent 20050194314 (2005).

Invited presentations

· Grand Rounds, UW Neurosurgery, “New and Improved Ways to Treat Hydrocephalus: Pursuit of a Smart Shunt,” August 14, 2013. Invited talk.

· Gordon Research Conference, Physics and Chemistry of Microfluidics, Opening talk in session on Paper-based Microfluidics. “A Tour of Physical Principles in Paper Microfluidics: The Ancient, The Old, and The New,” June 9-14, 2013. Invited talk.

· Molecular Medicine Tri-Con, Second Annual Point-of-Care Diagnostics Session, Innovation for the Future of Personalized Healthcare. “Sophisticated Point-of-Care Diagnostic Devices based on 2D Paper Networks,” February 11-12, 2013. Invited talk.

· SPIE Conference, Microfluidics, BioMEMS, and Medical Microsystems XI. “Programming paper networks for point of care diagnostics," March 9, 2013. Invited talk.

· Microfluidics 2.0: Second Annual Workshop on Capillary Based Microfluidics for Bioanalysis. “Programming Paper Networks for Automated Point of Care Assays,” Boston University (hosted by Catherine Klapperich’s Laboratory), November 20-December 1, 2012. Invited talk.

· Lab on a Chip World Congress, “Capillarity-based Paper Networks for Automated Point of Care Diagnostics,” September 25-26, 2012. San Diego, CA. Invited talk.

· Hydrocephalus Research Conference 2012. Session Co-Director for “Bioengineering Advances” with Sam Browd; and research talk, “Overview of bioengineering and hydrocephalus: 50 years in 30 minutes,” The Hydrocephalus Association, July 9-11 2012, Seattle, Washington.

· BMES Panel Discussion, “Navigating IP as a Student Panel Discussion,” Tuesday, May 1st, 2012.

· UW Mini Med School, March 13, 2012 (Graduation night). “Predicting and preventing disease: early diagnostics for all?” Lectures will be broadcast regularly on UWTV and publicly-available by on-demand streaming from the UWTV website. http://uwmedicine.washington.edu/Global/News/Events/Mini-Medical-School/Pages/Sessions.aspx

· UW Bioengineering Lunch and Learn Series, “Start-Up Companies,” March 6, 2012. Buddy Ratner and Barry Lutz.

· “Technical challenges and opportunities in point of care diagnostics.” Center for Nanotechnology/ Institute for Molecular Engineering and Sciences Seminar Series, University of Washington, January 17, 2012.

· “Point of care diagnostics for low resource settings.” Bioengineering Graduate Student Seminar, University of Washington, November 10, 2011.

· “Self-regulating paper network seeks adventure with synthetic biology,” Molecular Programming Project Workshop, Friday Harbor, Washington. June 16-18, 2011.

· “Microfluidics and Paper-Based Platforms for Point-Of-Care Testing.” Applied Pharmaceutical Analysis, Cambridge, Massachusetts. Theme "Smaller & Smarter: Rising up to meet Quantitative & Qualitative Bioanalytical Challenges", Session VII: Emerging Technologies, September 11-14, 2011.

· “Novel Microfluidic based Diagnostic Tools.” Center for Process Analytical Chemistry (CPAC) Summer Institute, Seattle, Washington, July 19-21, 2011.

· Presentation and Panel Discussion, Washington Biomedical and BBBB Association, Domesticating Global Health: "Doctor Ready". February 10, 2010.

· “Novel strategies for POC diagnostics and how they work: New diagnostic platforms and approaches." Center for Global Health Diagnostics, Course 1: Point of Care Diagnostics for Global Health, July 1, 2009.

· “Tunable Microeddies for Microfluidics: Non-contact Single-cell Trapping using Gentle Fluid Flow.” AVS International Symposium, BioMEMS Topical Conference, MEMS/NEMS for Biology and Medicine, October 2008. AVS Young Investigator Award.

· “Point-of-care platform for rapid disease diagnosis in the developing world.” NESAC/BIO Symposium: 25 Years at the Biointerface, July 2008.