Amalia S. (Meier) Magaret
Research Associate Professor, Laboratory Medicine, University of Washington
Joint Associate Member, Vaccine and Infectious Disease Division,
Fred Hutchinson

Education:

PhD Biostatistics, University of Washington, Seattle, WA 2001
MS Applied Statistics, University of Western Michigan, 1997

BS Chemistry and Math, University of Notre Dame, 1992

Contact info:

Harborview Medical Center
Virology Research Clinic
325 9th Ave, Box 359928
Seattle, WA  98104
ph:  206-520-4316
fax: 206-520-4371
amag@u.washington.edu

Links:

Current CV

Full publication list

 

Areas of clinical research interest

       Herpesviruses: My primary role is to provide statistical support to herpes research taking place at the Virology Research Clinic. We conduct observational studies examining the natural history of HSV in a wide variety of patient groups, e.g. men and women, HIV positive and negative, homosexual and heterosexual. We also evaluate transmission of HSV at birth from mother to infant, and participate in studies of candidate HSV vaccines and treatments.

        HIV: I have also contributed to clinical trials of HIV prevention as part of the Partners in Prevention study team, now known as the UW International Clinical Research Center.

 

  

Areas of statistical research interest

          Methods of assessing viral shedding: I have authored original work on

o   optimizing detection, (Magaret AS, Wald A, et al. 2007. Optimizing PCR positivity criterion for detection of HSV DNA on skin and mucosa. Journal of Clinical Microbiology;45(5): 1618-20.)

o   quantification, (Magaret AS, Johnston C, et al. 2009. Use of the designation "shedder" in mucosal detection of herpes simplex virus DNA involving repeated sampling. Sexually Transmitted Infections;85(4):270-5.)

o   optimal study design, (Magaret AS, Stanaway J. 2011. Sample size for a binomial proportion with autocorrelation. Stat Comm Infect Dis;3(1):Article 8. DOI: 10.2202/1948-4690.1036.)

o   optimal regression approach for crossover studies, (Magaret AS, Models for HSV shedding must account for two levels of overdispersion. University of Washington Biostatistics working paper series, #410. http://biostats.bepress.com/uwbiostat/paper410/

 

         Survival analysis for mismeasured outcomes:

o   Meier AS, Richardson BA, Hughes JP. 2003. Discrete proportional hazards models for mismeasured outcomes. Biometrics;59: 947-54.

o   Magaret AS. 2008. Incorporating validation subsets into discrete proportional hazards models for mismeasured outcomes. Statistics in Medicine;27(26):5456-70.

 

         Clinical trial design:

o   Magaret AS, Angus DC, Adhikari NKJ, Banura P, Kissoon N, Lawler J, Jacob ST. 2016. Design and of a multi-arm randomized clinical trial with no control arm. Contemp Clin Trials, 46:12-17.

 

Brief Biography