Amalia S. (Meier) Magaret
Research
Associate Professor, Laboratory Medicine, University of Washington
Joint Associate Member, Vaccine and Infectious Disease Division, Fred
Hutchinson
Education:
PhD
Biostatistics, University of Washington, Seattle, WA 2001
MS Applied Statistics, University of Western Michigan, 1997
BS Chemistry and Math,
University of Notre Dame, 1992
Contact info:
Harborview Medical
Center
Virology Research Clinic
325 9th Ave, Box 359928
Seattle, WA 98104
ph: 206-520-4316
fax: 206-520-4371
amag@u.washington.edu
Links:
Areas of clinical research interest
· Herpesviruses: My primary role is to provide statistical
support to herpes research taking place at the Virology Research Clinic. We conduct observational studies examining the natural history of HSV in a wide
variety of patient groups, e.g. men and women, HIV positive and negative,
homosexual and heterosexual. We also evaluate transmission of HSV at
birth from mother to infant, and participate in studies of candidate HSV
vaccines and treatments.
· HIV:
I have also contributed to clinical trials of HIV prevention as part of
the Partners in Prevention study team, now known as the UW International Clinical Research Center.
Areas of statistical research interest
·
Methods of
assessing viral shedding: I have authored original work on
o optimizing detection, (Magaret
AS, Wald A,
et al. 2007. Optimizing PCR positivity criterion for detection of HSV DNA on
skin and mucosa. Journal of Clinical Microbiology;45(5): 1618-20.)
o
quantification, (Magaret AS, Johnston C, et al. 2009. Use of the designation
"shedder" in mucosal detection of herpes simplex virus DNA involving
repeated sampling. Sexually Transmitted Infections;85(4):270-5.)
o
optimal study design,
(Magaret AS, Stanaway J. 2011.
Sample size for a binomial proportion with autocorrelation. Stat Comm Infect Dis;3(1):Article
8. DOI: 10.2202/1948-4690.1036.)
o
optimal regression approach for crossover studies, (Magaret AS, Models
for HSV shedding must account for two levels of overdispersion. University of Washington Biostatistics
working paper series, #410. http://biostats.bepress.com/uwbiostat/paper410/
·
Survival
analysis for
mismeasured outcomes:
o Meier
AS, Richardson BA, Hughes JP. 2003. Discrete
proportional hazards models for mismeasured outcomes. Biometrics;59: 947-54.
o Magaret AS. 2008. Incorporating validation subsets into
discrete proportional hazards models for mismeasured outcomes. Statistics in Medicine;27(26):5456-70.
·
Clinical
trial design:
o Magaret
AS, Angus DC, Adhikari NKJ, Banura P, Kissoon N,
Lawler J, Jacob ST. 2016. Design
and of a multi-arm randomized clinical trial with no control arm. Contemp Clin Trials, 46:12-17.
Brief Biography