Adam M. Alessio
aalessio@u.washington.edu

Research Associate Professor of Radiology
Adjunct Associate Professor of
Bioengineering and Mechanical Engineering


Diplomate ABSNM
Imaging Research Laboratory
University of Washington, Box 357987
Old Fisheries Center, Room 222
4000 15th Ave NE
Seattle, WA 98195-7987
Phone: 206-543-2419
Fax: 206-543-8356

 
 

I am currently working with CT and PET cardiac perfusion imaging, protocol optimization for PET and CT, and tomographic image reconstruction problems with a particular interest in statistical issues regarding data analysis, organization, and reconstruction. Examples of research available here.

Software | Papers | Book Chapters | Proceedings | Abstracts | External Links

Collaborative Initiatives

I am an active contributor to the following campaigns, particularly for appropriate protocol selection in Nuclear Medicine:

  • Image Gently: An initiative of the Alliance for Radiation Safety in Pediatric Imaging to promote radiation protection in the imaging of children.
  • Image Wisely: Campaign with objective of lowering the amount of radiation used in medically necessary imaging studies and eliminating unnecessary procedures.
  • SNMMI Dose Optimization: Radiation dose for all nuclear medicine and molecular imaging procedures should be optimized so that the patient receives the smallest possible amount of radiopharmaceutical that will provide the appropriate diagnostic information.

Software Tools

Papers

Adam Alessio Google Scholar Profile

  1. A. Alessio, K. Sauer, and A. Mohammad-Djafari, "System parameter estimation in tomographic inverse problems," in Bayesian inference and maximum entropy methods in science and engineering , vol. 568, A. Mohammad-Djafari, Ed. Melville, NY: Amer. Inst. Phys., 2001, pp. 181-191. pdf
  2. A. Alessio, K. Sauer, and C. A. Bouman, "MAP reconstruction from spatially correlated PET data," IEEE Trans Nuclear Science , vol. 50, pp. 1445-1451, 2003.
  3. A. Alessio, P. Kinahan, P. Cheng, H. Vesselle, and J. Karp, "PET/CT scanner instrumentation, challenges, and solutions," Radiologic Clinics of North America , vol. 42, pp. 1017-32, 2004. pdf
  4. Alessio, K. Sauer, and P. Kinahan, “Reconstruction of Deconvolved FORE Rebinned PET Measurements”, Physics in Medicine and Biology, vol 51, pp 77-93, 2006. pdf
  5. Alessio, P. Kinahan, and T. Lewellen, “Modeling and Incorporation of System Response Functions in 3D Whole Body PET,” IEEE Trans Medical Imaging, vol 25:7, pp 828-837, 2006. pdf
  6. P. Kinahan, A. Alessio, and J. Fessler, “Dual Energy CT Attenuation Correction Methods for Quantitative Assessment of Response to Cancer Therapy with PET/CT Imaging,” Tech in Cancer Research and Treatment, vol 5:4, 2006.
  7. Alessio and P. Kinahan, “Improved Quantitation for PET/CT Image Reconstruction with System Modeling and Anatomical Priors”, Medical Physics, vol 33:11, pp 4095-4103, 2006. pdf
  8. E. Ford, P. Kinahan, L. Hanlon, A. Alessio, J. Rajendran, D. Schwartz, and M. Phillips, “Tumor delineation using PET in Head and Neck Cancers: Threshold Contouring and Lesion Volumes”, Medical Physics, vol 33:11, pp 4280-4288, 2006.
  9. L. Gong, S. Pathak, A. Alessio, P. Kinahan, “Automatic arm removal in PET and CT images for deformable registration” Computerized Medical Imaging and Graphics, vol 30:8, pp 469-477, 2006.
  10. Alessio, S. Kohlmyer, K. Branch, G. Chen, J. Caldwell, and P. Kinahan, "Cine CT imaging for Attenuation Correction with Cardiac PET/CT," Journal of Nuclear Medicine , 48: 794-801, 2007. website
  11. Chen, K. Branch, A. Alessio, P. Pham, R. Tabibiazar, P. Kinahan, and J. Caldwell, “Effect Of Reconstruction Algorithms On Myocardial Blood Flow Measurement with N-13 Ammonia PET,” Journal of Nuclear Medicine, 48:1259-1265, 2007.
  12. Alessio, K. Sauer, and P. Kinahan, "Statistical Image Reconstruction from Correlated Data with Applications to PET," Physics in Medicine and Biology, 52:6133-6150, 2007. pdf
  13. Alessio, Schmitz, MacDonald, Wollenweber, Stearns, Ross, Ganin, Lewellen, and Kinahan, “Image Reconstruction for a Partially Collimated Whole Body PET Scanner”, IEEE Trans Nuclear Science, vol 55:3, pp 975-983, 2008. website
  14. L.R. MacDonald, R.E. Schmitz, A.M. Alessio, S.D. Wollenweber, C.W. Stearns, A. Ganin, R.L. Harrison, T.K. Lewellen and P.E. Kinahan, “Measured count-rate performance of the Discovery STE PET/CT scanner in 2D, 3D and partial collimation acquisition modes”, Physics in Medicine and Biology, vol 53, pp 3723-3738, 2008.
  15. K Lee, RS Miyaoka, TK Lewellen, AM Alessio, and PE Kinahan, “Impact on Image Noise of Incorporating Detector Blurring into Image Reconstruction for a Small Animal PET Scanner,” IEEE Trans Nuclear Science, vol 56:5, 2009.
  16. Alessio, Kinahan, Manchanda, Ghioni, Aldape, Parisi, “Weight-Based, Low-Dose Pediatric Whole-Body PET/CT Protocols,” Journal Nuclear Medicine, vol 50:10, pp 1570-1578, 2009. website
  17. C Liu, LA Pierce II, AM Alessio, PE Kinahan. "The impact of respiratory motion on tumor quantification and delineation in static PET/CT imaging." Physics in Medicine and Biology. vol 54:7345-7362, 2009. website
  18. Alessio, CW Stearns, S Tong, SG Ross, S Kohlmyer, A Ganin, PE Kinahan, "Application and Evaluation of a Measured Spatially Variant System Model for PET Image Reconstruction," IEEE Trans on Medical Imaging, vol. 29:3, 2010, pp. 938-949. website
  19. Alessio, PE Kinahan, K Champley, J Caldwell, "Attenuation-Emission Alignment in Cardiac PET/CT Based on Consistency Conditions," Medical Physics, vol 37:3, pp 1191-1200, 2010. website
  20. S Tong, AM Alessio, PE Kinahan, "Noise properties in PSF-based fully-3D PET image reconstruction: an experimental evaluation," Physics in Medicine and Biology, vol 55, pp 1453-1473, 2010. website
  21. C Liu, AM Alessio, L Pierce, K Thielemans, S Wollenweber, A Ganin, P Kinahan, "Quiescent period gating for PET/CT," Medical Physics, vol 37:9, pp 5037-5043, 2010.website
  22. Lockhart, MacDonald, Alessio, McDougald, Doot, Kinahan, "Quantifying and reducing the effect of calibration error on variability of PET/CT SUV measurements," Journal Nuclear Medicine, vol 52, pp 218-224, 2011. website
  23. S Tong, AM Alessio, PE Kinahan, H Liu, P Shi, "A robust state-space kinetics-guided framework for dynamic PET image reconstruction", Physics in Medicine and Biology, vol 56:8, pp 2481-2499, 2011. website
  24. Sammer, Shulkin, Alessio, Parisi, "Role of Limited Whole Body PET/CT in Pediatric Lymphoma" American Journal of Roentgenology, 196: 10.2214/AJR.10.6074, 2011. website
  25. Liu, Alessio, and Kinahan, "Respiratory motion correction for quantitative PET/CT using all detected events with internal-external motion correlation" Medical Physics, vol 38:5. pp 2715-2723, 2011. website
  26. Gu, Chakraborty, Champley, Alessio , Claridge , Rockne, Muzi, Krohn, Spence, Alvord, Anderson, Kinahan, and Swanson, "Applying A Patient-Specific Bio-Mathematical Model of Glioma Growth to Develop Virtual [18F]-FMISO PET Images," Mathematical Medicine & Biology, 2011. website
  27. MacDonald, Harrison, Alessio, Hunter, Lewellen, Kinahan, "Effective Count-Rates for PET Scanners with Reduced and Extended Axial Field of View" to appear Physics in Medicine and Biology, vol 56:12. pp 3629; 2011. website
  28. Alessio, M Sammer, G Phillips, V Manchanda, B Mohr, MT Parisi, "Evaluation of Optimal Acquisition Duration or Injected Activity for Pediatric FDG-PET/CT" Journal of Nuclear Medicine, vol 52, pp 1028-1034, 2011. website
  29. Tong, Alessio, Thielemans, Stearns, Ross, Kinahan, "Properties and Mitigation of Edge Artifacts in PSF-Based PET Reconstruction" IEEE Trans Nuclear Science, vol 58, pp 2264-2275, 2011. website
  30. Busch, Alessio, Caldwell, Gupta, Mao, Kadakia, Shuman, Budoff, Branch, "Myocardial hypo-enhancement on resting computed tomography angiography images accurately identifies myocardial hypoperfusion" Journal of Cardiovascular Computed Tomography, vol 5:6, pp 412-420, 2011. website
  31. Xia , Alessio, De Man, Manjeshwar, Asma, Kinahan, "Ultra-Low Dose CT Attenuation Correction for PET/CT", Physics in Medicine and Biology, vol 57, pp 309-328, 2012. website
  32. Pierce, Miyaoka, Lewellen, Alessio, Kinahan, "Detector Position Estimation for PET Scanners" Nuclear Instruments and Methods in Physics Research Section A, vol 677, pp 74-79, 2012. website
  33. Abella, Alessio, Mankoff, MacDonald, Vaquero, Desco, Kinahan, "Accuracy of CT-Based Attenuation Correction in PET/CT Bone Imaging," Physics in Medicine and Biology, vol 57:9, pp 2477-2490, 2012. website
  34. Swanson, Alessio, and Chapman,, "Estimated additional lifetime risk of cancer attributable to diagnostic CT in a pediatric bone marrow transplant cohort: Experience at a single academic institution", Open Journal of Clinical Diagnostics, vol 2, pp 4-9. 2012. website
  35. Chapman, Swanson, Phillips, Parisi, Alessio, "Pediatric Chest CT Radiation Dose Reduction: Protocol Refinement Based On Noise Injection For Pulmonary Nodule Detection Accuracy" Clinical Imaging, vol 37:2 , pp 334-341, 2013. website
  36. Shuman, Choi, Hsieh, Alessio, Kinahan, Busey, "Model Based Iterative Reconstruction (MBIR) versus Adaptive Statistical Iterative Reconstruction (ASIR) and FBP in 64 Channel Liver CT: Focal Lesion Detection, Lesion Conspicuity, and Image Noise" American Journal of Roentgenology. vol 200:5, 2013.
  37. Alessio, Bassingthwaighte, Glenny and Caldwell, "Validation of an axially distributed model for quantification of myocardial blood flow using 13N-ammonia PET," Journal of Nuclear Cardiology, vol 20:1, pp 64-75, 2013. website
  38. Alessio and LR MacDonald, "Quantitative Material Characterization from Multi-Energy Photon Counting CT", Medical Physics, vol 40:3, 2013. website
  39. Li, Alessio, Burnett, Lewellen, Miyaoka, Performance evaluation of small animal PET scanners with different system designs, IEEE Trans Nuclear Science, vol. 60:3, pp 1495-1502, 2013.
  40. Padia, Alessio, Kwan, Lewis, Vaidya, Minoshima, "Comparison of PET and Bremsstrahlung imaging to detect particle distribution in patients undergoing Yttrium-90 radioembolization for large hepatocellular carcinomas or associated portal vein thrombosis," Journal of Vascular and Interventional Radiology, Vol 24:8, pp 1147-1153, 2013.
  41. Khorsand, Song, Swanson, Alessio, Redding, Waldhausen, "Iatrogenic Radiation Exposure to Patients With Early Onset Spine and Chest Wall Deformities," Spine, vol 38:17, pp 1108-14, 2013.
  42. Xia, Alessio, and Kinahan, "Dual Energy CT used for Attenuation Correction with PET/CT," Medical Physics, vol 41:1, 2014.
  43. Phillips, Stanescu, Alessio, "Relationships of pediatric anthropometrics for CT protocol selection, " to appear American Journal of Roentgenology, 2014.
  44. Bindschadler, Modgil, Branch, La Riviere, Alessio, "Comparison of Blood Flow Models and Acquisitions for Quantitative Myocardial Perfusion Estimation from Dynamic CT," Physics in Medicine and Biology, vol 59:7, 2014. website
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Selected Book Chapters and Review Articles

  • R. Schmitz, A. Alessio, P. Kinahan, “The Physics of PET/CT scanners,” In: PET and PET/CT: A Clinical Guide. E. Lin and A. Alavi, Eds., New York, Thieme; 2005 and 2009.
  • A. Alessio and P. Kinahan, “PET Image Reconstruction,” In: Nuclear Medicine (2nd ed.). Henkin et al., Eds., Philadelphia, Elsevier; 2006. pdf
  • E. Lin E, A. Alessio. "What are the basic concepts of temporal, contrast, and spatial resolution in cardiac CT?" Journal of Cardiovascular Computed Tomography. vol 3, pp 403-408, 2009. website
  • JB Bassingthwaighte, GM Raymond, E Butterworth, A Alessio, & JH Caldwell, "Multiscale modeling of metabolism, flows, and exchanges in heterogeneous organs." Ann NY Acad Sci vol. 1188, 2010, pp. 111-120.website
  • S Tong, AM Alessio, PE Kinahan. "Image reconstruction for PET/CT scanners: past achievements and future challenges," Imaging in Medicine, vol 2:5, pp. 529-545. 2010. website
  • Alessio, Rahmim, "Resolution modeling enhances PET imaging," point/counterpoint in Medical Physics, 40, 2013. website

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Selected Conference Proceedings

  • A. Alessio, K. Sauer, and C. A. Bouman, "MAP reconstruction from spatially correlated PET data," Proc. of IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Norfolk, VA, vol. 2, pp. 907-911, 2002. pdf
  • A. Alessio, K. Sauer, C. Bouman, and P. Kinahan, "PET Statistical Reconstruction with Modeling of Axial Effects of FORE," Proc. of IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Portland, vol. 4, pp. 2804-2807, 2003. pdf
  • A. Alessio, K. Sauer, and P. Kinahan, "PET Reconstruction from Deconvolved FORE Data," Proc. of IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Portland, vol. 3, pp. 2032-2035, 2003.
  • P. Kinahan, J. A. Fessler, A. Alessio, and T. K. Lewellen, "Quantitative Attenuation Correction for PET/CT Using Iterative Reconstruction of Low-Dose Dual-Energy CT," Proc. of IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Rome, pp. 3285 - 3289, 2004.
  • R. L. Harrison, A. M. Alessio, P. E. Kinahan, and T. K. Lewellen, " Signal to Noise Ratio in Simulations of Time-of-Flight Positron Emission Tomography," Proc. of IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Rome, pp. 4080-4083, 2004.
  • A. Alessio, P. Kinahan, and T. Lewellen, "Modeling and Incorporation of System Response Functions in 3D Whole Body PET," Proc. of IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Rome, 2004. pdf
  • A. Alessio, P. Kinahan, and T. Lewellen, "Improved Quantitation for PET/CT Image Reconstruction with System Modeling and Anatomical Priors," SPIE Medical Imaging, San Diego, 2005. Proc. SPIE Vol 5747, p. 695-703. pdf
  • Ford, P. Kinahan, M .Phillips, A. Alessio, L. Hanlon, “Tumor-delineation uncertainties in FDG-PET and FMISO-PET images and the effect on radiation therapy plans,” AAPM, Seattle, 2005. Medical Physics, vol. 32:6, pp 19944-1945.
  • R. Harrison, A. Alessio, P. Kinahan, and T. Lewellen,”The Effects of Object Size, Attenuation, Scatter, and Random Coincidences on SNR in Simulations of Time-of-Flight PET,” IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Puerto Rico, pp. 1900-1904, 2005.
  • P. Kinahan, P. Cheng, A. Alessio, T. Lewellen. “A Quantitative Approach to a Weight-Based Scanning Protocol for PET Oncology Imaging,” IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Puerto Rico, pp 1886-1890, 2005.
  • A. Alessio, P. Kinahan, R. Harrison, and T. Lewellen, “Measured Spatially Variant System Response for PET Image Reconstruction,” IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Puerto Rico, pp. 1986-1990, 2005. pdf
  • P. Kinahan, L. MacDonald, L. Ng, A. Alessio, W.P. Segars, B. Tsui, and S. Pathak, ”Compensating For Patient Respiration In PET/CT Imaging With The Registered And Summed Phases (RASP) Procedure,” IEEE International Symp on Biomedical Imaging, Arlington, VA, vol. 2, 1104-1107, 2006.
  • L. MacDonald, R. Schmitz, S. Wollenweber, C. Stearns, A. Ganin, R. Harrison, A. Alessio, T. Lewellen, P. Kinahan, “Count-Rate Performance of the DSTE PET Scanner Using Partial Collimation” IEEE Nucl. Sci. Symp. and Med. Imaging Conf., San Diego, 2006. M11-109.
  • A. Alessio, J. Caldwell, G. Chen, K. Branch, P. Kinahan, “Attenuation-Emission Alignment in Cardiac PET/CT with Consistency Conditions” IEEE Nucl. Sci. Symp. and Med. Imaging Conf., San Diego, 2006. M14-327. pdf
  • L. MacDonald, R. Schmitz, A. Alessio, R. Harrison, T. Lewellen, P. Kinahan, “Estimating Live-Time for New PET Scanner Configurations” IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Honolulu, 2007.
  • P. Kinahan, A. Alessio, P. Segars, L. MacDonald, and S. Wollenweber, “Quantitative Evaluation of Respiratory Gated Whole-Body PET/CT Imaging Incorporating Respiration Variability” IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Honolulu, 2007.
  • A. Alessio, S. Kohlmyer, and P Kinahan, “Consistency Driven Respiratory Phase Alignment and Motion Compensation in PET/CT” IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Honolulu, 2007. pdf
  • A. Alessio and P. Kinahan, “Application Of A Spatially Variant System Model For 3-D Whole-Body PET Image Reconstruction” IEEE Inter Symp on Biomedical Imaging, Paris, 2008. pdf
  • A. Alessio and L. MacDonald, “Spatially Variant Positron Range Modeling Derived from CT for PET Image Reconstruction” IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Dresden, pp 3637 – 3640, 2008. pdf
  • W. Huh, J.A. Fessler, A.M. Alessio, P.E. Kinahan, "Fast kVp-Switching Dual Energy CT for PET Attenuation Correction," IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Orlando, pp 2510-15, 2009.
  • L. Pierce, R. Miyaoka, T. Lewellen, A. Alessio, P. Kinahan, "Determining block detector positions for PET scanners," IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Orlando, pp 2976-80, 2009.
  • T. Xia, A. Alessio, P. Kinahan, "Limits of ultra-low dose CT attenuation correction for PET/CT," IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Orlando, pp 3074-79, 2009.
  • S. Tong, A. Alessio, P. Kinahan, "Evaluation of Noise Properties in PSF-Based PET Image Reconstruction," IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Orlando, pp 3042-47, 2009.
  • T. Xia, A. Alessio, P. Kinahan, "Noise properties as a function of energy of monoenergetic images from DECT used for attenuation correction with PET/CT and SPECT/CT," SPIE Medical Imaging, San Diego, 2010. Proc. SPIE, 7622-76.
  • J Xu, N Subramanian, A Alessio, S Hauck, "Impulse C vs. VHDL for Accelerating Tomographic Reconstruction," IEEE Symposium on Field-Programmable Custom Computing Machines, Charlotte, NC, 2010.
  • T Xia, A Alessio, P Kinahan. "Spectral shaping for ultra-low dose CT attenuation correction in PET/CT," 1st International Conf on Image Formation in X-ray CT, Salt Lake City, UT, pp 105-108, 2010.
  • Alessio and GS Phillips, "A Pediatric CT Dose and Risk Estimator," technical innovation in Pediatric Radiology, vol 40:11, pp 1816-21, 2010. website
  • Gelfand, Sharp, Treves, Fahey, Parisi and Alessio, "Estimated cumulative radiation dose from PET/CT in children with malignancies" Letter to Editor of Pediatric Radiology. vol 40:10, pp 1712-13, 2010. website
  • S Tong, AM Alessio, K Thielemans, C Stearns, S Ross, PE Kinahan, "Properties of Edge Artifacts in PSF-Based PET Reconstruction", IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Knoxville, 2010.
  • Alessio and PJ La Rivière, "Constrain static target kinetic iterative image reconstruction for 4D cardiac CT imaging," SPIE Electronic Imaging, Proc. SPIE 7873, 78730S; doi:10.1117/12.884662, 2011. website
  • Alessio, KR Branch, JH Caldwell, JB Bassingthwaighte, "Comparison of models and acquisition techniques for estimation of myocardial blood flow from CT," SPIE Medical Imaging, Proc. SPIE 7965, 7965I, 2011.website
  • Xia, Alessio, Asma, Manjeshwar, DeMan, Kinahan "Quantitative task performance of PET/CT with ultra-low dose CT attenuation correction", SPIE Medical Imaging, 2012.
  • Alessio, LM MacDonald, "Quantitative soft tissue characterization from multi-energy photon counting CT," The 2nd International Conf on Image Formation in X-Ray CT, 2012.
  • T Xia, AM Alessio, PE Kinahan, "Noise and bias properties of PET images using DECT based attenuation correction," The 2nd International Conf on Image Formation in X-Ray CT, 2012.
  • Bowen, Pierce, Alessio, Liu, Kinahan, “Enhancing Clinical Utility of Respiratory-Gated PET/CT Using Patient Respiratory Trace Classification,” IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Anaheim, 2012.
  • Long, Cheng, Rui, De Man, Alessio, Asma and Kinahan, "Analysis of Ultra-Low Dose CT Acquisition Protocol and Reconstruction Algorithm Combinations for PET Attenuation Correction," Fully 3D Image Reconstruction, 2013.
  • Modgil, Alessio, Bindschadler, Little, Rigie, Vargas and La Rivière, "Multi-dimensional sinogram restoration for myocardial blood flow estimation from dose-reduced dynamic CT," Fully 3D Image Reconstruction, 2013.
  • Rui, Long, Asma, Alessio, Kinahan, De Man, "Analysis of Optimal CT Spectrum for PET Attenuation Correction," IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Seoul, 2013.
  • Kim, Alessio, De Man, Asma, Kinahan, "Direct Reconstruction of CT-based Attenuation Correction Images for PET with Cluster-Based Penalties," IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Seoul, 2013.
  • Harrison, Jacobs, Elston, Alessio, Byrd, Rockne, Hawkins-Daarud, Muzi, Jackson, Swanson, Kinahan, "Integrating a Three-Dimensional Spatiotemporal Glioma Model with a PET Simulation System to Create Patient-Specific FMISO Images," IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Seoul, 2013.
  • Bindschadler, Modgil, Branch, La Riviere, Alessio, "Simulation Evaluation of Quantitative Myocardial Perfusion Assessment from Cardiac CT," SPIE Medical Imaging, San Diego 2014.
  • Modgil, Alessio, Bindschadler, La Riviere, "Adaptive temporal smoothing of sinogram data using Karhunen-Loeve (KL) transform for myocardial blood flow estimation from dose-reduced dynamic CT," SPIE Medical Imaging, San Diego 2014.

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Selected Abstracts

  • P. M. Cheng, P. Kinahan, A. Alessio, H. Vesselle, S. Pathak, L. Ng, C. Comtat, M. Defrise, and T. Lewellen, "Post-Reconstruction Partial Volume Correction in PET/CT Imaging Using CT Information," Radiological Society of North America, Chicago, pp. 371, 2004.
  • P. Kinahan, A. Alessio, J. Fessler, P. Cheng, H. Vesselle, and T. Lewellen, "Quantitative Dual Energy CT-Based Attenuation Correction for PET/CT Oncology Imaging," Radiological Society of North America, Chicago, pp. 401, 2004.
  • Alessio, P. Kinahan, and T. K. Lewellen, "Reconstruction Methods for Reducing Partial Volume Errors in PET/CT Systems," Journal of Nuclear Medicine, vol. 46, pp. 469PP (abstract), 2005.
  • Kinahan PE, Alessio AM, Lewellen TK, “A Simple Dual Energy Method for CT-Based Attenuation Correction That Accounts for Contrast Agents in PET/CT Imaging.” Journal of Nuclear Medicine, vol. 46, pp. 113P (abstract), 2005.
  • Ford E. Kinahan P, Phillips M, Alessio A, Hanlon L. “Tumor-delineation uncertainties in FDG-PET and FMISO-PET images and the effect on radiation therapy plans.” Medical Physics vol. 32(6). pp. (abstract), 2005.
  • Kinahan, PE, Vesselle H, Alessio A, MacDonald L, Kohlmyer SG, Michael C, Wille M, Miesbauer D, O'Day P. “Improving the Clinical Practicality of 4D Respiratory Gated PET with Simultaneous Whole-body Sinogram and Listmode Acquisition.” Molecular Imaging and Biology, (abstract) 2006.
  • Alessio AM, Kinahan PE. “Statistical Reconstruction of Targeted Regions with Application to CT and PET Cardiac Imaging.” American Journal of Roentgenology (supplement) Vol. 186 No. 4. pp A46 (abstract), 2006.
  • MacDonald LR, Kinahan PE, Alessio AM, Segars WP, Tsui BM. “Compensating for Patient Respiration in PET/CT Imaging with Respiration Aligned Summed Phases (RASP).” American Journal of Roentgenology (supplement) Vol. 186 No. 4. pp A28 (abstract), 2006.
  • P. E. Kinahan, H. Vesselle, J. Williams, C. Stearns, R. Schmitz, A. Alessio, L. Macdonald, O. Mawlawi, T. Turkington and T. Lewellen. “Performance evaluation of an integrated PET/CT scanner: Discovery STE,” Journal of Nuclear Medicine, vol. 46, pp 392P. (abstract), 2006.
  • P. E. Kinahan, H. Vesselle, L. Macdonald, A. Alessio, S. Kohlmyer and T. Lewellen, “Whole-body Respiratory Gated PET/CT,” .Journal of Nuclear Medicine, vol. 46, pp 187P. (abstract), 2006.
  • Vesselle H, Kohlmyer S, Alessio A, and Kinahan P, “Incorporation of Cine CTAC to Reduce the Banana Artifact in PET/CT Imaging,” Journal of Nuclear Medicine, vol. 46, pp 187P. (abstract), 2006.
  • Alessio, S. Kohlmeyer, G. Chen, K. Branch, J. Caldwell and P. Kinahan, “Cine CT imaging for PET attenuation correction with cardiac PET/CT,” Journal of Nuclear Medicine, vol. 46, pp 57P. (abstract), 2006.
  • Chen GP, Branch K, Alessio AM, Pham P, Tabibiazar R, Caldwell JH, “Effect of Reconstruction Algorithms on Myocardial Blood Flow Measurement with PET N-13 Ammonia”, Journal of Nuclear Cardiology, vol. 13, no. 4, pp S11(abstract), 2006.
  • Alessio, P. Kinahan, G. Chen, K. Branch, and J. Caldwell, “Quantifying Attenuation-Emission Alignment In Cardiac PET/CT Imaging”, Journal of Nuclear Cardiology, vol 13 no. 4, pp s33(abstract), 2006.
  • Branch KR, Mitsumori L, Caldwell J, Alessio A, Warren W, Busch J, Chen G, Kohlmyer S, Shuman W, “Pilot Study of Triple Rule Out Protocol Using CT,” North American Society for Cardiac Imaging, Las Vegas, 2006.
  • Branch KR, Busch JL, Alessio AM, Mitsumori L, Kohlmyer S, Caldwell JH, Shuman WP. Prospective ECG-gating for 64-slice Cardiac CTA: Initial Experience. J Nucl Cardiol 2007 (abstract).
  • Kinahan, Wollenweber, Alessio, Kohlmyer, MacDonald, Lewellen, and Ganin. "Impact of respiration variability on respiratory gated whole-body PET/CT imaging," Journal of Nuclear Medicine, vol 48, pp 196P (abstract), 2007.
  • Kinahan, Alessio, Wollenweber, Ng, Lewellen, Wanner, Kohlmyer, and MacDonald. "Motion-free PET: Compensating for patient respiration in whole-body PET/CT imaging," Journal of Nuclear Medicine, vol 48, pp 197P   (abstract), 2007.
  • Kohlmyer, Alessio, Kinahan and Fessler. "4D PET temporal smoothing with respiratory induced Fourier filter (RIFF)." Journal of Nuclear Medicine, vol 48, pp 197P (abstract), 2007.
  • Alessio, Caldwell, Branch, Kohlmyer, Ross, and Kinahan. "Assessment of attenuation-emission alignment in cardiac PET/CT imaging," Journal of Nuclear Medicine, vol. 48,pp 415P (abstract), 2007.
  • Alessio, "Targeted Statistical Image Reconstruction for Cardiac CT Imaging," Workshop on Solving Computational Challenges in Medical Imaging. Seattle, WA. July 2007.
  • Alessio, Butterworth, Caldwell, and, Bassingthwaighte, “Quantitative PET Myocardial Perfusion Through Integrated Volume Manipulation, Display, and Modeling,” Workshop on Multi-scale Modelling of the Heart. Auckland, NZ. March 2008.
  • Alessio, Stearns, Wollenweber, Ross, Ganin, Kinahan, and Kohlmyer, “Application and Evaluation of a Measured System Model in Fully-3D PET Image Reconstruction,” Journal of Nuclear Medicine, vol 49, 64P, (abstract), 2008.
  • Alessio, Manchanda, Kinahan, Ghioni, Aldape, Busch, Parisi, “Initial Experience with Weight-Based, Low-Dose Pediatric PET/CT Protocols,” Journal of Nuclear Medicine, vol 49, 85P, (abstract), 2008.
  • Alessio A, Caldwell J. “Automatic Attenuation and Emission Alignment in Cardiac PET/CT Based on Consistency Conditions.” Multimodality Cardiovascular Molecular Imaging Symposium, NIH, Bethesda, MD, April 30, 2009. Journal of Nuclear Medicine 50:656-665, 2009.
  • Liu, Alessio, Pierce, Thielemans, Wollenweber, Yue, Kohlmyer, Ganin, Kinahan, “Quiescent phase respiratory gating for PET/CT. ” Journal of Nuclear Medicine (abstract), 2009.
  • K Branch, A Alessio, K Kanal, W Shuman, J Caldwell, J Earls, "Reduction in Estimated Lifetime Cancer Incidence and Mortality Using Cardiac Prospective ECG Triggered CT Compared to Retrospective Gated CT", American College Cardiology Annual Meeting, 55:A67.E633, Atlanta, Ga, 2010.
  • T Chapman, S Friedman, A Alessio, "Estimated Additional Lifetime Risk of Cancer Attributable to Diagnostic CT in a Pediatric Bone Marrow Transplant Cohort: Experience at a Single Academic Institution." Association University Radiologists Annual Meeting (abstract), San Diego, 2010.
  • C Liu, A Alessio, P Kinahan, "Respiratory motion correction for PET/CT with internal-external motion correlation," Journal of Nuclear Medicine (abstract), vol 51:78, Salt Lake City, 2010.
  • M Sammer, A Alessio, B Mohr, V Manchanda, G. Phillips, M Parisi, "Selection of optimal acquisition duration or injected activity for pediatric FDG-PET/CT," Journal of Nuclear Medicine (abstract), vol 51: 486, Salt Lake City, 2010.
  • A Le Pogam, A Alessio, B Kandel, A Kirov, O Barret, P Fernandez, X Cheze Le Rest, S Visvikis, "Comparison of PET reconstruction resolution recovery and post-reconstruction deconvolution for partial volume effect correction (PVC) in PET," Journal of Nuclear Medicine (abstract), vol 51:577, Salt Lake City, 2010.
  • L MacDonald, R Harrison, A Alessio, W Hunter, T Lewellen, P Kinahan, "Effective count-rates for PET scanners with reduced and extended axial field of view," Journal of Nuclear Medicine (abstract), vol 51: 1410, Salt Lake City, 2010.
  • Alessio, JB Bassingthwaighte, S Bahrainy, JH Caldwell, "Myocardial blood flow quantification in cardiac PET imaging with a distributed model," 1st International Sino-American Conference on Nuclear Medicine, Beijing, 2011.
  • Alessio, A Patel, R Lautamaki, FM Bengel, JB Bassingthwaighte, JH Caldwell, "Validation of axially-distributed models for myocardial blood flow estimation from N-13 ammonia and Rb-82 cardiac PET imaging," International Conference of Non-Invasive Cardiovascular Imaging, Amsterdam, 2011.
  • S Tong, A Alessio, K Thielemans, C Stearns, S Ross, P Kinahan, "Edge artifacts in PSF-based PET image reconstruction: Characterization and mitigation," Journal of Nuclear Medicine (abstract), vol 52, San Antonio, 2011.
  • S Bahrainy, A Alessio, J Bassingthwaighte, J Caldwell, "Clinical application of a distributed model for quantitative assessment of myocardial blood flow with PET," Journal of Nuclear Medicine (abstract), vol 52, San Antonio, 2011.
  • K Swanson, S Gu, G Chakraborty, K Champley, A Alessio, R Rockne, M Muzi, K Krohn, P Kinahan, "Predictive simulation of patient-specific [18F]FMISO-PET images," Journal of Nuclear Medicine (abstract), vol 52, San Antonio, 2011.
  • T Xia, A Alessio, B De Man, R Manjeshwar, E Asma, P Kinahan, "Ultra-low dose CT attenuation correction for PET/CT," Journal of Nuclear Medicine (abstract), vol 52, San Antonio, 2011.
  • Busch, Alessio, Caldwell, Mao, Kadakia, Gupta, Shuman, Budoff , Branch, "Contrast Enhanced Myocardium on Computed Tomography Angiography Images Accurately Identifies True Hypoperfusion," Society of Cardiovascular Computed Tomography, Denver, 2011.
  • Aldape, Alessio, Watkins, Petkavich, Craig , Hoke, Parisi, "Monitoring patient injection and scan time for quality assurance of PET SUV quantitation," Western Regional Society of Nuclear Medicine, 2011.
  • Aldape, Alessio, Parisi, Watkins, Petkavich, Craig Abrahamson, David Rosenbaum, "Communication of Radiation Doses from Pediatric NM Procedures with Parents and Guardians," Western Regional Society of Nuclear Medicine, 2011.
  • Phillips, Stanescu, Alessio, "Comparison of Age-based vs. Size-based Categories for Pediatric CT Protocols," American Roentgen Ray Society, Vancouver, 2012.
  • Alessio, "Spectral CT Imaging for Soft Tissue and Plaque Characterization," Conference of Peace through Mind Brain Science: Advances in Molecular Medicine and Imaging: Between Bench and Bedside, Hamamatsu, Japan 2012.
  • Alessio, Vesselle, Lewis, Matesan, Behnia, Suhy, deBoer, Maniawski, Minoshima, "Feasibility of low-dose FDG for whole-body TOF PET/CT oncologic workup" Journal of Nuclear Medicine (abstract), vol 53, Miami, 2012. media coverage
  • Nesterov et al, "The Fourteen Reflections of Perfusion: a Cross-Comparison Study of Seven Rb-82 PET Models Implemented in Eight Software Tools" American Society Nuclear Cardiology, Baltimore, 2012.
  • Byrd, Alessio, Stearns, Ross, Ganin, and Kinahan, "Characterization of partial volume errors in PET through analytic simulation," Journal of Nuclear Medicine, Vancouver 2013.
  • Alessio, Farrell, and Fahey, "Survey of radiopharmaceutical dosing strategies for bone and PET scans," Journal of Nuclear Medicine, Vancouver 2013. media coverage
  • Swanson, Vining, White, Krengel, Alessio, Friedman, Song, "Pediatric Spine CT Radiation Dose Reduction: Protocol Refinement Based On Measurement Variation At Simulated Lower Radiation Acquisitions", International Meeting on Advanced Spine Techniques, Vancouver, 2013.
  • Bindschadler, Modgil, Branch, La Riviere, Alessio, "Comparison of myocardial blood flow models for quantitative perfusion estimation from Dynamic CT", Society of Cardiovascular Computed Tomography, Montreal, 2013.
  • Ly, Eagle, Meyer, Alessio, "Patient Motion Tracking for Medical Imaging Using 3D Sensing", Biomedical Engineering Society, Seattle, 2013.
  • Nesterov, Sciagrà, Alessio, Declerck, Ficaro, Slomka, Yoshinaga, Nekolla, Case, deKemp, Prior, "A cross-comparison study of 10 software tools for quantification of 82Rb myocardial perfusion PET," European Association of Nuclear Medicine, Lyon, France, 2013.
  • Alessio, So, Lee, "Image-based partial scan artifact reduction for dynamic contrast enhanced CT," Radiological Society of North America, Chicago, Dec 5, 2013.
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Last Revised: 6 April 2014