Adam M. Alessio
aalessio@u.washington.edu

Research Assistant Professor
Imaging Research Laboratory
Department of Radiology
University of Washington, Box 357987
Old Fisheries Center, Room 220
4000 15th Ave NE
Seattle, WA 98195-7987
Phone: 206-543-2419
Fax: 206-543-8356

 
 

I am currently working with cardiac perfusion imaging and tomographic image reconstruction problems with a particular interest in statistical issues regarding data collection, organization, and reconstruction.

CT Dose and Risk Tool for educating physicians and technologists on the amount of radiation dose and cancer risk from basic diagnostic procedures.

Papers

  1. A. Alessio, K. Sauer, and A. Mohammad-Djafari, "System parameter estimation in tomographic inverse problems," in Bayesian inference and maximum entropy methods in science and engineering , vol. 568, A. Mohammad-Djafari, Ed. Melville, NY: Amer. Inst. Phys., 2001, pp. 181-191. pdf
  2. A. Alessio, K. Sauer, and C. A. Bouman, "MAP reconstruction from spatially correlated PET data," IEEE Trans Nuclear Science , vol. 50, pp. 1445-1451, 2003.
  3. A. Alessio, P. Kinahan, P. Cheng, H. Vesselle, and J. Karp, "PET/CT scanner instrumentation, challenges, and solutions," Radiologic Clinics of North America , vol. 42, pp. 1017-32, 2004. pdf
  4. Alessio, K. Sauer, and P. Kinahan, “Reconstruction of Deconvolved FORE Rebinned PET Measurements”, Physics in Medicine and Biology, vol 51, pp 77-93, 2006. pdf
  5. Alessio, P. Kinahan, and T. Lewellen, “Modeling and Incorporation of System Response Functions in 3D Whole Body PET,” IEEE Trans Medical Imaging, vol 25:7, pp 828-837, 2006. pdf
  6. P. Kinahan, A. Alessio, and J. Fessler, “Dual Energy CT Attenuation Correction Methods for Quantitative Assessment of Response to Cancer Therapy with PET/CT Imaging,” Tech in Cancer Research and Treatment, vol 5:4, 2006.
  7. Alessio and P. Kinahan, “Improved Quantitation for PET/CT Image Reconstruction with System Modeling and Anatomical Priors”, Medical Physics, vol 33:11, pp 4095-4103, 2006. pdf
  8. E. Ford, P. Kinahan, L. Hanlon, A. Alessio, J. Rajendran, D. Schwartz, and M. Phillips, “Tumor delineation using PET in Head and Neck Cancers: Threshold Contouring and Lesion Volumes”, Medical Physics, vol 33:11, pp 4280-4288, 2006.
  9. L. Gong, S. Pathak, A. Alessio, P. Kinahan, “Automatic arm removal in PET and CT images for deformable registration” Computerized Medical Imaging and Graphics, vol 30:8, pp 469-477, 2006.
  10. Alessio, S. Kohlmyer, K. Branch, G. Chen, J. Caldwell, and P. Kinahan, "Cine CT imaging for Attenuation Correction with Cardiac PET/CT," Journal of Nuclear Medicine , 48: 794-801, 2007. website
  11. Chen, K. Branch, A. Alessio, P. Pham, R. Tabibiazar, P. Kinahan, and J. Caldwell, “Effect Of Reconstruction Algorithms On Myocardial Blood Flow Measurement with N-13 Ammonia PET,” Journal of Nuclear Medicine, 48:1259-1265, 2007.
  12. Alessio, K. Sauer, and P. Kinahan, "Statistical Image Reconstruction from Correlated Data with Applications to PET," Physics in Medicine and Biology, 52:6133-6150, 2007. pdf
  13. Alessio, Schmitz, MacDonald, Wollenweber, Stearns, Ross, Ganin, Lewellen, and Kinahan, “Image Reconstruction for a Partially Collimated Whole Body PET Scanner”, IEEE Trans Nuclear Science, vol 55:3, pp 975-983, 2008. website
  14. L.R. MacDonald, R.E. Schmitz, A.M. Alessio, S.D. Wollenweber, C.W. Stearns, A. Ganin, R.L. Harrison, T.K. Lewellen and P.E. Kinahan, “Measured count-rate performance of the Discovery STE PET/CT scanner in 2D, 3D and partial collimation acquisition modes”, Physics in Medicine and Biology, vol 53, pp 3723-3738, 2008.

Book Chapters

  • R. Schmitz, A. Alessio, P. Kinahan, “The Physics of PET/CT scanners,” In: PET and PET/CT: A Clinical Guide. E. Lin and A. Alavi, Eds., New York, Thieme; 2005.
  • A. Alessio and P. Kinahan, “PET Image Reconstruction,” In: Nuclear Medicine (2nd ed.). Henkin et al., Eds., Philadelphia, Elsevier; 2006. pdf

Selected Conference Proceedings

  • A. Alessio, K. Sauer, and C. A. Bouman, "MAP reconstruction from spatially correlated PET data," Proc. of IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Norfolk, VA, vol. 2, pp. 907-911, 2002. pdf
  • A. Alessio, K. Sauer, C. Bouman, and P. Kinahan, "PET Statistical Reconstruction with Modeling of Axial Effects of FORE," Proc. of IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Portland, vol. 4, pp. 2804-2807, 2003. pdf
  • A. Alessio, K. Sauer, and P. Kinahan, "PET Reconstruction from Deconvolved FORE Data," Proc. of IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Portland, vol. 3, pp. 2032-2035, 2003.
  • P. Kinahan, J. A. Fessler, A. Alessio, and T. K. Lewellen, "Quantitative Attenuation Correction for PET/CT Using Iterative Reconstruction of Low-Dose Dual-Energy CT," Proc. of IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Rome, pp. 3285 - 3289, 2004.
  • R. L. Harrison, A. M. Alessio, P. E. Kinahan, and T. K. Lewellen, " Signal to Noise Ratio in Simulations of Time-of-Flight Positron Emission Tomography," Proc. of IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Rome, pp. 4080-4083, 2004.
  • A. Alessio, P. Kinahan, and T. Lewellen, "Modeling and Incorporation of System Response Functions in 3D Whole Body PET," Proc. of IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Rome, 2004. pdf
  • A. Alessio, P. Kinahan, and T. Lewellen, "Improved Quantitation for PET/CT Image Reconstruction with System Modeling and Anatomical Priors," SPIE Medical Imaging, San Diego, 2005. Proc. SPIE Vol 5747, p. 695-703. pdf
  • Ford, P. Kinahan, M .Phillips, A. Alessio, L. Hanlon, “Tumor-delineation uncertainties in FDG-PET and FMISO-PET images and the effect on radiation therapy plans,” AAPM, Seattle, 2005. Medical Physics, vol. 32:6, pp 19944-1945.
  • R. Harrison, A. Alessio, P. Kinahan, and T. Lewellen,”The Effects of Object Size, Attenuation, Scatter, and Random Coincidences on SNR in Simulations of Time-of-Flight PET,” IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Puerto Rico, pp. 1900-1904, 2005.
  • P. Kinahan, P. Cheng, A. Alessio, T. Lewellen. “A Quantitative Approach to a Weight-Based Scanning Protocol for PET Oncology Imaging,” IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Puerto Rico, pp 1886-1890, 2005.
  • A. Alessio, P. Kinahan, R. Harrison, and T. Lewellen, “Measured Spatially Variant System Response for PET Image Reconstruction,” IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Puerto Rico, pp. 1986-1990, 2005. pdf
  • P. Kinahan, L. MacDonald, L. Ng, A. Alessio, W.P. Segars, B. Tsui, and S. Pathak, ”Compensating For Patient Respiration In PET/CT Imaging With The Registered And Summed Phases (RASP) Procedure,” IEEE International Symp on Biomedical Imaging, Arlington, VA, vol. 2, 1104-1107, 2006.
  • L. MacDonald, R. Schmitz, S. Wollenweber, C. Stearns, A. Ganin, R. Harrison, A. Alessio, T. Lewellen, P. Kinahan, “Count-Rate Performance of the DSTE PET Scanner Using Partial Collimation” IEEE Nucl. Sci. Symp. and Med. Imaging Conf., San Diego, 2006. M11-109.
  • A. Alessio, J. Caldwell, G. Chen, K. Branch, P. Kinahan, “Attenuation-Emission Alignment in Cardiac PET/CT with Consistency Conditions” IEEE Nucl. Sci. Symp. and Med. Imaging Conf., San Diego, 2006. M14-327. pdf
  • L. MacDonald, R. Schmitz, A. Alessio, R. Harrison, T. Lewellen, P. Kinahan, “Estimating Live-Time for New PET Scanner Configurations” IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Honolulu, 2007. (to appear)
  • P. Kinahan, A. Alessio, P. Segars, L. MacDonald, and S. Wollenweber, “Quantitative Evaluation of Respiratory Gated Whole-Body PET/CT Imaging Incorporating Respiration Variability” IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Honolulu, 2007. (to appear)
  • A. Alessio, S. Kohlmyer, and P Kinahan, “Consistency Driven Respiratory Phase Alignment and Motion Compensation in PET/CT” IEEE Nucl. Sci. Symp. and Med. Imaging Conf., Honolulu, 2007. pdf
  • A. Alessio and P. Kinahan, “Application Of A Spatially Variant System Model For 3-D Whole-Body PET Image Reconstruction” IEEE Inter Symp on Biomedical Imaging, Paris, 2008. pdf

Selected Abstracts

  • P. M. Cheng, P. Kinahan, A. Alessio, H. Vesselle, S. Pathak, L. Ng, C. Comtat, M. Defrise, and T. Lewellen, "Post-Reconstruction Partial Volume Correction in PET/CT Imaging Using CT Information," Radiological Society of North America, Chicago, pp. 371, 2004.
  • P. Kinahan, A. Alessio, J. Fessler, P. Cheng, H. Vesselle, and T. Lewellen, "Quantitative Dual Energy CT-Based Attenuation Correction for PET/CT Oncology Imaging," Radiological Society of North America, Chicago, pp. 401, 2004.
  • Alessio, P. Kinahan, and T. K. Lewellen, "Reconstruction Methods for Reducing Partial Volume Errors in PET/CT Systems," Journal of Nuclear Medicine, vol. 46, pp. 469PP (abstract), 2005.
  • Kinahan PE, Alessio AM, Lewellen TK, “A Simple Dual Energy Method for CT-Based Attenuation Correction That Accounts for Contrast Agents in PET/CT Imaging.” Journal of Nuclear Medicine, vol. 46, pp. 113P (abstract), 2005.
  • Ford E. Kinahan P, Phillips M, Alessio A, Hanlon L. “Tumor-delineation uncertainties in FDG-PET and FMISO-PET images and the effect on radiation therapy plans.” Medical Physics vol. 32(6). pp. (abstract), 2005.
  • Kinahan, PE, Vesselle H, Alessio A, MacDonald L, Kohlmyer SG, Michael C, Wille M, Miesbauer D, O'Day P. “Improving the Clinical Practicality of 4D Respiratory Gated PET with Simultaneous Whole-body Sinogram and Listmode Acquisition.” Molecular Imaging and Biology, (abstract) 2006.
  • Alessio AM, Kinahan PE. “Statistical Reconstruction of Targeted Regions with Application to CT and PET Cardiac Imaging.” American Journal of Roentgenology (supplement) Vol. 186 No. 4. pp A46 (abstract), 2006.
  • MacDonald LR, Kinahan PE, Alessio AM, Segars WP, Tsui BM. “Compensating for Patient Respiration in PET/CT Imaging with Respiration Aligned Summed Phases (RASP).” American Journal of Roentgenology (supplement) Vol. 186 No. 4. pp A28 (abstract), 2006.
  • P. E. Kinahan, H. Vesselle, J. Williams, C. Stearns, R. Schmitz, A. Alessio, L. Macdonald, O. Mawlawi, T. Turkington and T. Lewellen. “Performance evaluation of an integrated PET/CT scanner: Discovery STE,” Journal of Nuclear Medicine, vol. 46, pp 392P. (abstract), 2006.
  • P. E. Kinahan, H. Vesselle, L. Macdonald, A. Alessio, S. Kohlmyer and T. Lewellen, “Whole-body Respiratory Gated PET/CT,” .Journal of Nuclear Medicine, vol. 46, pp 187P. (abstract), 2006.
  • Vesselle H, Kohlmyer S, Alessio A, and Kinahan P, “Incorporation of Cine CTAC to Reduce the Banana Artifact in PET/CT Imaging,” Journal of Nuclear Medicine, vol. 46, pp 187P. (abstract), 2006.
  • Alessio, S. Kohlmeyer, G. Chen, K. Branch, J. Caldwell and P. Kinahan, “Cine CT imaging for PET attenuation correction with cardiac PET/CT,” Journal of Nuclear Medicine, vol. 46, pp 57P. (abstract), 2006.
  • Chen GP, Branch K, Alessio AM, Pham P, Tabibiazar R, Caldwell JH, “Effect of Reconstruction Algorithms on Myocardial Blood Flow Measurement with PET N-13 Ammonia”, Journal of Nuclear Cardiology, vol. 13, no. 4, pp S11(abstract), 2006.
  • Alessio, P. Kinahan, G. Chen, K. Branch, and J. Caldwell, “Quantifying Attenuation-Emission Alignment In Cardiac PET/CT Imaging”, Journal of Nuclear Cardiology, vol 13 no. 4, pp s33(abstract), 2006.
  • Branch KR, Mitsumori L, Caldwell J, Alessio A, Warren W, Busch J, Chen G, Kohlmyer S, Shuman W, “Pilot Study of Triple Rule Out Protocol Using CT,” North American Society for Cardiac Imaging, Las Vegas, 2006.
  • Branch KR, Busch JL, Alessio AM, Mitsumori L, Kohlmyer S, Caldwell JH, Shuman WP. Prospective ECG-gating for 64-slice Cardiac CTA: Initial Experience. J Nucl Cardiol 2007 (abstract).
  • Kinahan, Wollenweber, Alessio, Kohlmyer, MacDonald, Lewellen, and Ganin. "Impact of respiration variability on respiratory gated whole-body PET/CT imaging," Journal of Nuclear Medicine, vol 48, pp 196P (abstract), 2007.
  • Kinahan, Alessio, Wollenweber, Ng, Lewellen, Wanner, Kohlmyer, and MacDonald. "Motion-free PET: Compensating for patient respiration in whole-body PET/CT imaging," Journal of Nuclear Medicine, vol 48, pp 197P   (abstract), 2007.
  • Kohlmyer, Alessio, Kinahan and Fessler. "4D PET temporal smoothing with respiratory induced Fourier filter (RIFF)." Journal of Nuclear Medicine, vol 48, pp 197P (abstract), 2007.
  • Alessio, Caldwell, Branch, Kohlmyer, Ross, and Kinahan. "Assessment of attenuation-emission alignment in cardiac PET/CT imaging," Journal of Nuclear Medicine, vol. 48,pp 415P (abstract), 2007.
  • Alessio, "Targeted Statistical Image Reconstruction for Cardiac CT Imaging," Workshop on Solving Computational Challenges in Medical Imaging. Seattle, WA. July 2007.
  • Alessio, Butterworth, Caldwell, and, Bassingthwaighte, “Quantitative PET Myocardial Perfusion Through Integrated Volume Manipulation, Display, and Modeling,” Workshop on Multi-scale Modelling of the Heart. Auckland, NZ. March 2008.
  • Alessio, Stearns, Wollenweber, Ross, Ganin, Kinahan, and Kohlmyer, “Application and Evaluation of a Measured System Model in Fully-3D PET Image Reconstruction,” Journal of Nuclear Medicine (abstract to appear), 2008.
  • Alessio, Manchanda, Kinahan, Ghioni, Aldape, Busch, Parisi, “Initial Experience with Weight-Based, Low-Dose Pediatric PET/CT Protocols,” Journal of Nuclear Medicine (abstract to appear), 2008.

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Last Revised: 17.08.08